Identification of a Mutation in FGF23 Involved in Mandibular Prognathism
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چکیده
منابع مشابه
Identification of a Mutation in FGF23 Involved in Mandibular Prognathism
Mandibular prognathism (MP) is a severe maxillofacial disorder with undetermined genetic background. We collected a Chinese pedigree with MP which involved in 23 living members of 4 generations. Genome-wide linkage analysis were carried out to obtain the information in this family and a new MP-susceptibility locus, 12pter-p12.3 was identified. Whole-exome sequencing identified a novel heterozyg...
متن کاملMandible in Mandibular Prognathism
Department of Orthodontics, School of Dentistry, National Taiwan University, Taipei; Department of Orthodontics, School of Dentistry, Kaohsiung Medical University, Kaohsiung; Institute of Biomechanical Engineering, National Cheng Kung University, Tainan. Received: 3 May 2002. Revised: 3 June 2002. Accepted: 9 July 2002. Reprint requests and correspondence to: Dr. Hong-Po Chang, Department of Or...
متن کاملGenome Scan for Locus Involved in Mandibular Prognathism in Pedigrees from China
BACKGROUND It is well known that genetic components play an important role in the etiology of mandibular prognathism, but few susceptibility loci have been mapped. METHODOLOGY In order to identify linkage regions for mandibular prognathism, we analyzed two Chinese pedigrees with 6,090 genome-wide single-nucleotide polymorphism (SNP) markers from Illumina Linkage-12 DNA Analysis Kit (average s...
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Causation of a disease and a symptom generally is classified as genetic inheritance and environmental factors. A disease caused by a single gene disorder is defined as a disease that is attributed to a monogenic factor. A single gene disorder has been reported in more than 3,000 hereditary diseases. On the other hand, a polygenic or multifactorial disease is attributed to some susceptibility ge...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep11250